Mercury is a toxic pollutant that can negatively impact the population’s health and the environment. The research on atmospheric mercury is of critical concern because of the diverse process that this pollutant suffers in the atmosphere as well as its deposition capacity, which can provoke diverse health issues. The Minamata Convention encourages the protection of the adverse effects of mercury, where research is a part of the strategies and atmospheric modelling plays a critical role in achieving the proposed aim. This paper reviews the study of modelling atmospheric mercury based on the southern hemisphere (SH). The article discusses diverse aspects focused on the SH such as the spatial distribution of mercury, its emissions projections, interhemispheric transport, and deposition. There has been a discrepancy between the observed and the simulated values, especially concerning the seasonality of gaseous elemental mercury and total gaseous mercury. Further, there is a lack of research about the emissions projections in the SH and mercury deposition, which generates uncertainty regarding future global scenarios. More studies on atmospheric mercury behaviour are imperative to better understand the SH’s mercury cycle.